An international team that included researchers from the University of Haifa has identified a genetic mutation associated with Crohn’s Disease that was previously connected to Parkinson’s disease. The discovery was recently published in the prestigious journal Science Translational Medicine.
“Researchers have not identified until now any similar or associated mechanisms involved in Crohn’s, a bowel disease, and Parkinson’s, a degenerative brain disease,” Atzmon said. “One possibility is that there is no connection, and that this gene is responsible for different and unrelated functions in the body. Another possibility we examined is that the enhanced expression of an area in this gene encourages phosphorylation, influencing a cascade of events each of which leads in turn to the outbreak of either or both of these diseases.”
Crohn’s is an inflammatory bowel disease that develops in three to 14 people out of every 100,000 in any given year. The disease is particularly prevalent in …